Amitraz is a triazapentadiene compound, a member of the amidine chemical family. It is an insecticide and acaricide used to control red spider mites, leaf miners, scale insects, and aphids. Amitraz is a topical parasite control agent. The action of amitraz is not thoroughly understood, but it is suspected to work by interfering with the nervous system of susceptible parasites.

Amitraz is primarily used to treat the skin disease demodectic mange. Amitraz is often used in dogs for management of a serious skin parasite that causes demodectic mange. Amitraz is also used for control of ticks in dogs. Some forms of amitraz are available without a prescription but should not be administered unless under the supervision and guidance of a veterinarian.

Amitraz is a powerful compound that inhibits the tick from "feeding" on your dog. The tick's sharp barbed mouth parts become paralyzed and cannot pierce the skin. For attached ticks, they detach! In both cases, Amitraz is lethal to ticks. Amitraz is highly effective insecticide, used for animal ectoparasites. It is a broad spectrum insecticide, widely used for cattle, sheep, goats and pigs. It has rapid action on the control of animal ectoparasites, such as , mites, ticks and keds etc., and the compound persists on hair and wool long enough to control all stages of the parasite. Meanwhile, in agriculture and horticulture, the outstanding miticidal activity of Amitraz has been shown to control pear psylla and mites in deciduous fruit, mites in citrus and a wide range of pest species in cotton. Amitraz is relatively safe to predatory insects and bees.