Chlorpyrifos

Chlorpyrifos is one of the most-widely used active ingredients for pest control products in the world. It is used to protect a number of important agricultural crops, such as corn, citrus, alfalfa, peanuts, and others, from pest insect attack. It is also used to control over 250 non-agricultural insect and arthropod pests, including subterranean termites, cockroaches, fleas, ants, and others, that are found in and around structures and on lawns, trees and shrubs. Chlorpyrifos was first registered in 1965 and has been on the market for more than thirty years. Today, it is registered in more than 98 countries worldwide, including most developed nations. Dursban* and Lorsban* insecticides are frequently used trade names for chlorpyrifos.

Chlorpyrifos is one of about 100 organophosphate (OP) insecticides on the market today. It is used to kill insect pests by disrupting their nervous system. Chlorpyrifos has an advantage over other products in that it is effective against a wide range of plant-eating insect pests. Chlorpyrifos is a pesticide that is a member of one of the principal classes of pesticides used in the U.S. and in most industrialized countries-the organophosphates. Organophosphate pesticides are neurotoxins. These neurotoxins poison the nervous systems of unwanted insects by interfering with an enzyme in the brain, acetylchlolinesterase, which regulates signals between brain cells. Very similar enzymes are found in the human nervous system, and thus chlorpyrifos and other organophosphates can cause injury to the human brain.

Chlorpyrifos and other insecticide OPs are inhibitors of acetylcholinesterase (ACh-ase) as are also carbamates, which is an enzyme vital to the nervous systems of animals and humans. The transmission of impulses across certain nerve junctions (synapses), (including, in humans, those of the autonomic nervous system) involves the release of a transmitter chemical, acetylcholine (ACh). The stimulant effect on ACh is rapidly cancelled by ACh-ase activity. The inhibiting effect of OPs on ACh-ase results in sustained high levels of ACh with consequent serious and widespread disruption of nervous activity. Symptoms of acute chlorpyrifos poisoning in humans include headache, nausea, dizziness, muscle twitching, weakness, increased sweating and salivation, and occur when cholinesterase activity has been reduced by about 50%. Unconsciousness, convulsions, and death can result with sufficient exposure. These symptoms are common to all organophosphate insecticides with delayed symptoms one to four weeks after exposure of numbness, tingling, weakness and cramping in the lower limbs which can progress into paralysis.

CAS No.: 921-88-2
Molecular formula: C9H11Cl3NO3PS
Molecular weight: 350.6
Specifications: 97% TC, 95% TC, 48% EC, 40% EC