Chenodeoxycholic Acid (Chenodeoxycholate)
Chenodeoxycholic acid is a bile acid that is used to treat gallstones. This is a chemical which occurs naturally in bile, where it helps control the concentration of cholesterol in the blood. As an orally administered drug it is given as an alternative to surgery in the treatment of gallstones. It acts by reducing levels of cholesterol in the bile, helping gallstones that are made predominantly of cholesterol to dissolve. Chenodeoxycholic acid is ineffective with stones of a high calcium or bile acid content. Its benefits are increased by weight loss and a diet high in fibre and low in fat. The drug dissolves gallstones in 3 to 18 months and the progress of the treatment is assessed regularly by ultrasound or X-ray. To prevent recurrence of gallstones drug treatment my be continued after the stones have disappeared.
Other names for Chenodeoxycholic acid include: Chenodiol, Chenic Acid, and CDCA.
The most abundant bile acids in humans are cholic acid and chenodeoxycholic acid. They are usually conjugated in amide linkage with the amino acid glycine or taurine. The cholic acid conjugates with glycine and taurine are called glycocholate and taurocholate, respectively.
CAS Number: 474–25-9
Molecular Formula: C24H40O4