Chondroitin Sulfate

Chondroitin sulfate is a large water loving molecule. Stimulates the secretion of joint fluid & increases viscosity. It also absorbs the enzymes which naturally break down joints. Has powerful anti-inflammatory action on connective tissue diseases & has the ability to regulate immune response.

Chondroitin sulfate belongs to a family of heteropolysaccharides called glycosaminoglycans or GAGs. Glycosaminoglycans were formerly known as mucopolysaccharides. GAGs in the form of proteoglycans comprise the ground substance in the extracellular matrix of connective tissue. It is made up of linear repeating units containing D-galactosamine and D-glucuronic acid. It is found in humans in cartilage, bone, cornea, skin and the arterial wall. This type of chondroitin sulfate is sometimes referred to as chondroitin sulfate A or galactosaminoglucuronoglycan sulfate. The amino group of galactosamines in the basic unit of chondroitin sulfate A is acetylated, yielding N-acetyl-galactosamine; there is a sulfate group esterified to the 4-position in N-acetyl-galactosamine. (Chondroitin sulfate A is also sometimes called chondroitin 4-sulfate). Its molecular weight ranges from 5,000 to 50,000 daltons and contains about 15 to 150 basic units of D-galactosamine and D-glucuronic acid.

Glucosamine and chondroitin sulphate are substances found naturally in the body. Glucosamine is a form of amino sugar that is believed to play a role in cartilage formation and repair. Chondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity. Both materials are sold as dietary or nutritional supplements. They are extracted from animal tissue: glucosamine from crab, lobster or shrimp shells; and chondroitin sulfate from animal cartilage, such as tracheas or shark cartilage.

Chondroitin sulfate is widely distributed in animal tissues and possibly plays an important role in different types of metabolic reactions as well as being a protective agent of joints, internal wall of blood vessels, skin, bones, etc. In cartilage, glycosaminoglycans have a protective function, CS stabilizes fibrous and cellular elements of the connective tissue and, at the same time, lubricates and protects the membranes. It has been studied as a product in chondroprotection and cartilage repair, and also in the fields of dermatology, cosmetics, coronary heart diseases, angiogenesis, anti-arteriosclerosis, anti-thrombosis, wound healing, connective tissue regeneration, ophtalmology, traumatisms, inhibition of stone formation, periodonitis, adhesion prevention, radiology, etc.

Chondroitin sulphate stops the degradation providing the cartilage with resistance and elasticity, and slows cartilage breakdown by protecting it from destructive enzymes. It has both pain relieving and regenerating activities in the cartilage. The moisturizing and hydrating properties of the product due to its high hygroscopicity help to maintain the elasticity of the cutaneous tissue.

CAS Number: [9007-28-7] 39455-18-0
Molecular formula: C14H19NNa2O14S

Packing: 25Kg paper drum. Storage in tightly sealed containers at room temperature, dark and dry place is recommended.

Chondroitin sulfate research information

NIAMS-funded analysis of glucosamine/chondroitin sulfate trials shows probable usefulness for osteoarthritis, independent, high-quality clinical trials recommended - A systematic analysis of clinical trials on glucosamine and chondroitin sulfate for treating osteoarthritis (OA) has shown that these compounds may have some efficacy against the symptoms of this most common form of arthritis, in spite of problems with trial methodologies and possible biases.
NIH awards study on glucosamine/chondroitin Sulphate for knee osteoarthritis - The first U.S. multicenter study to investigate the dietary supplements glucosamine and chondroitin sulfate for knee osteoarthritis has been awarded by the National Center for Complementary and Alternative Medicine (NCCAM) in collaboration with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), two components of the National Institutes of Health (NIH).
Glucosamine and chondroitin sulfate - What are glucosamine (G) and chondroitin sulfate (CS) and what do they do? Glucosamine and chondroitin sulfate are building blocks that the body uses to form a variety of soft tissue structural elements. One such essential structure is the cartilage that is found in joints (e.g., knee joint). The functions of articular (joint) cartilage, which covers the ends of the bones that form the joint, are to provide near frictionless motion, and to act as a shock absorber.
Chondroitin sulfate for relief of osteoarthritis symptoms in prostate cancer patients - Patients often use chondroitin sulfate in combination with glucosamine to relieve osteoarthritis symptoms. Unfortunately, chondroitin sulfate also appears to play such a major role in cancer biology that using it may be risky.
Glucosamine and chondroitin sulfate - Abstract of scientific review article regarding studies on the clinical efficacy and pharmacology of glucosamine-chondroitin sulfate as well as guidelines for responsible nutraceutical product selection.
Osteoarthritis treatments - Glucosamine and chondroitin sulfate supplements - For patients who have evidence of osteoarthritis in their spine (as seen on an x-ray) and who have had other causes of back pain and neck pain ruled out by their health care provider, glucosamine sulfate and chondroitin sulfate may be a treatment option.