Ipriflavone

Ipriflavone (7-isopropoxyisoflavone) is a synthetic derivative of naturally occuring isoflavones, flavonoid compounds found in soybeans and other plants that act like the female hormone estrogen in the body. It has been widely studied in humans and found effective for inhibiting bone resorption and enhancing bone formation, the net result being an increase in bone density and a decrease in fracture rates in osteoporotic women.

While ipriflavone appears to enhance estrogen's effect, it does not possess intrinsic estrogenic activity, making it an attractive adjunct or alternative to conventional hormone replacement therapy. Preliminary studies have also found ipriflavone effective in preventing bone loss associated with chronic steroid use, immobility, ovariectomy, renal osteodystrophy, and gonadotrophin hormone-releasing hormone agonists. In addition, it holds promise for the treatment of other metabolic diseases affecting the bones, including Paget's disease of the bone, hyperparathyroidism, and tinnitus caused by otosclerosis.

Ipriflavone promotes the incorporation of calcium into bone. It also inhibits bone breakdown. Many clinical studies, including numerous double-blind studies, have clearly shown that long-term treatment with ipriflavone (along with 1,000 mg supplemental calcium per day) is both safe and effective in halting bone loss in postmenopausal women or in women who have had their ovaries removed Ipriflavone is absorbed from the small intestine; from there it enters the portal circulation. Greater absorption is obtained with food, and lipid-containing foods especially enhance its absorption. Ipriflavone is metabolized in the liver. The two major metabolites are 7-hydroxy-ipriflavone and 7-(1-carboxy-ethoxy)-isoflavone. Ipriflavone and its metabolites are distributed to the various tissues of the body via the systemic circulation.. Ipriflavone has also been found to improve bone density in cases of osteoporosis.

For some time, postmenopausal women in Europe and Japan have taken ipriflavone supplements to maintain the density and strength of their bones and to guard against fractures and other complications associated with the bone-thinning disease known as osteoporosis. In the United States, ipriflavone supplements have recently become available. Ipriflavone's bone-strengthening effect is enhanced by taking both vitamin D and calcium along with it. Postmenopausal women taking the prescription drug calcitonin to prevent bone loss may boost its effectiveness by taking ipriflavone.

Ipriflavone is also known as 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one; 7-(1-methylethoxy)-3-phenyl-4H-1-benzopyran-4-one; 7-isopropoxy-3-phenylchromone and 7-isopropoxyisoflavone. Ipriflavone is abbreviated as IP. It is a solid substance that has poor solubility in water.

Function and Uses: Have similar function of female Hormone, have availability for improving osteoporosis of female, used for medicine of osteoporosis. Used for increase of avoirdupois, especially for increase of muscle. Used as additive of feed. Also used for human, have availability of ant1-angina, ant1-pain of faucbs. Used for regulator of calcium.

Molecular Formula: C18H16O3
Molecular Weight: 280.33
CAS No.: 35212-22-7
Appearance: White Crystalline powder, insoluble in water and soluble in methanol.
Assay: 99% min.