Luteolin

Luteolin is a naturally occurring compound found in foods including parsley, artichoke leaves, celery, peppers, olive oil, rosemary, lemons, peppermint, sage, thyme, and many others. Luteolin has antioxidant, anti-inflammatory, anti-allergic, anticancer, and immune-modulating properties to suppress hyperactive immune systems. Luteolin is a potent hypoglycemic agent and improves insulin sensitivity. Luteolin may help promote healthy blood glucose levels and help in weight management for Syndrome X. Externally luteolin can be used for skin allergic/inflammatory disorders and for skin cancer prevention. Luteolin is a promising agent for use in ophthalmology: for prevention and treatment of cataract and of vascular eye disorders. Luteolin is an active inhibitor of different hyaluronidases, which modify hyaluronic acid. Hyaluronic acid, a heteropolysaccharide, is one the polymers that accounts for the toughness and flexibility of cartilage and tendon.
Luteolin can helps the body withstand radiation and chemotherapy. In a study from Japan, researchers went looking for the factor in rooibos tea that was protecting DNA from radiation-induced free radicals. They discovered that the protective factor is luteolin. They then treated mice with pure luteolin. The flavonoid gave dramatic protection to the bone marrow and spleen against radiation. It was better than any other plant derivative tested (see Free Radicals chart). They then tested luteolin in conjunction with doxorubicin (Adriamycin), a common chemo-therapeutic drug known for its cardiac and bone marrow toxicity. Doxorubicin caused lipid peroxidation to rise in bone marrow to 5.9 times normal and cardiac rose to 1.5 times normal. Luteolin provided dramatic protection against this drug-induced free radical damage. Bone marrow peroxidation decreased 91% and CPK levels (an indication of heart damage) were normalized by luteolin. Importantly, luteolin did not interfere with the therapeutic effects of doxorubicin.

Luteolin exhibits spasmolytic effects: Luteolin significantly antagonized acetylcholine- and histamine-induced contraction of smooth muscle in the guinea pig model of modified air overflow, and showed strong anti-histamine properties. Luteolin displays anti-leishmanial activity. Luteolin displays strong antinociceptive (against pain originating from peripheral nerves) action in mice. This is in accordance with the fact that Luteolin is an active principle of Brazilian plant Wedelia paludosa, traditionally used against the variety of disorders, including painful conditions. Luteolin is a Super-Nutrient from a class of naturally occurring molecules known as bioflavonoids. Luteolin neutralizes free radicals such as superoxide, the hydroxyl radical, and other reactive oxygen compounds to help reduce oxidative stress and may help reduce inflammation, regulate hyperactive immune systems, and promote healthy carbohydrate metabolism.

CAS No.: 491-70-3
Molecular Formula: C15H12O6
Molecular Weight: 288.26

Specification
Characteristic: Yellow crystalline powder
Purity(HPLC): 98.0% min.

Continue reading here: Ipriflavone

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Readers' Questions

  • robinia
    What is luteolin good for?
    6 months ago
  • Luteolin is a flavonoid, a type of plant compound commonly found in vegetables, fruits, and herbs. It is known for its strong antioxidant and anti-inflammatory properties, which offer several potential health benefits. Here are some of its known uses:
    1. Anti-inflammatory effects: Luteolin helps reduce inflammation in the body by inhibiting the activity of enzymes and molecules involved in the inflammatory response. It may assist in managing chronic inflammatory conditions like arthritis, asthma, and heart disease.
    2. Antioxidant activity: Luteolin helps protect cells from oxidative stress and damage caused by free radicals. This antioxidant effect may contribute to reducing the risk of chronic diseases such as cancer, cardiovascular disease, and neurodegenerative disorders.
    3. Cancer prevention: Luteolin has been studied for its potential anti-cancer properties. It may help inhibit the growth and spread of cancer cells, block tumor formation, and induce cancer cell death. However, more research is needed to fully understand its usage in cancer treatment.
    4. Neuroprotective effects: Luteolin has shown promise in protecting brain cells from oxidative stress and inflammation, which are often associated with age-related neurodegenerative diseases like Alzheimer's and Parkinson's disease. It may also enhance cognitive function.
    5. Anti-allergic activity: Luteolin has been found to possess anti-allergic properties by inhibiting the release of histamine and other inflammatory mediators. This may be helpful in managing allergic conditions like asthma, hay fever, and atopic dermatitis.
    6. Cardiovascular health: The antioxidant and anti-inflammatory properties of luteolin may benefit heart health. It may help reduce blood pressure, improve blood flow, and prevent the formation of blood clots, thereby reducing the risk of heart disease.
    7. Anti-diabetic properties: Luteolin may help regulate blood sugar levels and improve insulin sensitivity, making it potentially beneficial for individuals with diabetes or those at risk of developing the condition.
    8. It is important to note that while luteolin shows promise in various areas, further research is necessary to fully establish its efficacy, optimal dosage, and potential side effects. As with any supplement or treatment, it is advisable to consult with a healthcare professional before using luteolin for specific health purposes.
    • Marina
      What is luteolin used for?
      9 months ago
    • Luteolin is a natural flavonoid compound found in various plant sources, such as fruits, vegetables, and herbs. It is known to have potential therapeutic effects and is used for several purposes. Some of the common uses of luteolin include:
      1. Anti-inflammatory properties: Luteolin can help reduce inflammation in the body by inhibiting the production of inflammatory molecules, such as cytokines and enzymes.
      2. Antioxidant effects: Luteolin acts as an antioxidant, protecting cells from damage caused by free radicals and oxidative stress.
      3. Allergy relief: Luteolin may help alleviate allergy symptoms by inhibiting the release of histamines and reducing the activity of inflammatory cells involved in allergic reactions.
      4. Neuroprotective effects: Luteolin has shown promising results in protecting and preserving brain health. It may help reduce the risk of neurodegenerative diseases, such as Alzheimer's and Parkinson's, by reducing inflammation and oxidative stress in the brain.
      5. Anti-cancer potential: Research suggests that luteolin may possess anti-cancer properties by inhibiting the growth and spread of cancer cells, promoting apoptosis (cell death) in cancer cells, and reducing tumor formation.
      6. Cardiovascular health: Luteolin may offer cardiovascular benefits by improving blood flow, reducing inflammation in blood vessels, and preventing the oxidation of cholesterol, which can lead to the formation of plaques.
      7. Anti-diabetic effects: Luteolin has been studied for its potential in controlling blood sugar levels and improving insulin sensitivity, which may be beneficial for individuals with diabetes.
      8. It is important to note that while luteolin has shown promising effects in various studies, more research is needed to fully understand its potential benefits and its optimal dosage for different conditions. As with any supplement or natural compound, it is advisable to consult a healthcare professional before using luteolin for any specific purpose.