Alpha GPC (L-alphaglycerylphosphorylcholine, also known as choline alfoscerate) is a phospholipid metabolite found concentrated in neuronal membranes. Made from lecithin, Alpha GPC is extremely well absorbed and crosses the blood brain barrier. Alpha-GPC is a naturally occuring metabolite of phosphatidylcholine (an important component of cell membranes).
In the brain, Alpha GPC supports brain function and learning processes by directly increasing the synthesis and secretion of acetylcholine. Alpha GPC protects neurons and improves signal transmission by serving as a precursor to membrane phospholipids.
Alpha-GPC (alpha glycerylphosphorylcholine) is a precursor to acetylcholine, which is the most abundant neurotransmitter in the body and is typically very low in hard training athletes. Low acetylcholine levels are directly related to high levels of somatostatin. Thus, higher levels of acetylcholine and lower levels of somatostatin result in higher levels of growth hormone. Coleus Forskholii (forskolin) has been shown to increase the "biological amplifying system" by increasing the synthesis of the 3, '5'-cyclic ester of AMP (cAMP). cAMP is generated from ATP by the action of adenyl cyclase that is coupled to hormone receptors by G-proteins, a binding protein. GH-RH acts via cAMP to promote the synthesis and release of hGH from pituitary glands.