Tylosin is a macrolide, bacteriostatic antibiotic. It is similar in structure, mechanism of action, and spectrum as that of erythromycin. Tylosin is a macrolide antibiotic related structurally to erythromycin, tylosin is produced from Streptomyces fradiae. It is made naturally by the bacterium “Streptomyces fradiae” and acts to inhibit bacterial protein synthesis by inhibiting the 50S ribosome, a cellular structure only certain bacteria have and use to make internal proteins. It occurs as an almost white to buff-colored powder with a pKa of 7.1. It is slightly soluble in water and soluble in alcohol. Tylosin is considered to be highly lipid soluble. The tartrate salt is soluble in water. The injectable form of the drug (as the base) is in a 50% propylene glycol solution.
Tylosin is an antibiotic veterinary drug for the treatment of disease in food producing animals, including cattle, swine, and poultry, and for growth promotion in pigs. In small animals, tylosin is used for its anti-inflammatory properties in the large intestine rather than for its ability to fight infection. While few formal studies have been performed to examine this non-antibacterial property of tylosin, this has not stopped tylosin from being widely used in the treatment of colitis in pets. Tylosin is a broad spectrum antibiotic; it has good anti-bacterial activity against most pathogenic organism such as gram positive bacterium, some gram negative bacterium, vibrio, spirochete, coccidian, etc. It is one of the first-choice drugs against infections caused by mycoplasma. Tylosin is fast acting; it can be absorbed quickly after oral administration and distributed widely in the organs (mainly concentrated in lung, liver, kidney, spleen and gallbladder). Bioavailability of Tylosin is high, which makes Tylosin's action rapid and long lasting. However, Tylosin is very safe. And residue in tissues is very rare. It is eliminated from the body upon withdrawal of the drug. Tylosin is very stable, against environmental conditions, feed processing, etc. Tylosin is a good growth promotant. It cannot only prevent diseases, but continual use also increases growth rate and can improve breeding efficiency. Because of Tylosin's broad spectrum activity it is quite effective when used as the only antibiotic for animal and poultry thus, cross-drug-resistance is avoided.
Chemical Formula: C46H80N2O13
Molecular Weight: 869.15
Cas No.: 108050-54-0
Specification: Tilmicosin consists of 82-88% cis isomer and 12-18% trans isomer, as determined by liquid chromatographic assay. (Assay: Min. 85%)