Gamma-aminobutyric acid (GABA)
Gamma Aminobutyric Acid (GABA) is a non-essential amino acid found mainly in the human brain and eyes. It is considered an inhibitory neurotransmitter, which means it regulates brain and nerve cell activity by inhibiting the number of neurons firing in the brain. GABA is referred to as the "brain's natural calming agent." By inhibiting over-stimulation of the brain, GABA may help promote relaxation and ease nervous tension. This supplement provides only the naturally occurring L-form as found in food and in the body.
Gamma-aminobutyric acid (GABA) is a neurotransmitter in widely divergent species. In humans, GABA acts at inhibitory synapsess in the brain and spinal cord. As in the other contexts where GABA acts as a transmitter, the inhibition results from a hyperpolarization of the synaptic transmembrane potential of the inhibited neuron, which is elicited by the binding of GABA molecules to their receptorss in the post-synaptic membrane. This binding opens ion channels to allow either the flow of chloride or potassium ions into or out of the cell. In insects GABA mediates muscle activation at synapses between nerves and muscle cells and also the stimulation of certain glands. So far three general classes of GABA receptor are known, more than one of which is often represented in the same organisms. These include both so-called ionotropic receptors, which are ion channels themselves, and metabotropic receptors, which are G protein-coupled receptors that open ion channels via intermediaries (G proteins).
With regard to the human brain, it has been asserted that GABA signals interfere with the registration and consolidation stages of memory formation. This is thought to be possible because the GABA system is found in the hippocampus, an area of brain which has been implicated in memory formation.
Gamma-Aminobutyric acid (GABA) is the product of a biochemical decarboxylation reaction of glutamic acid by the vitamin pyridoxal. GABA serves as a inhibitory neurotransmitter to block the transmission of an impulse from one cell to another in the central nervous system. Medically, GABA has been used to treat both epilepsy and hypertension where it is thought to induce tranquility in individuals who have a high activity of manic behavior and acute agitation.
GABA is required as an inhibitory neurotransmitter to block the transmission of an impulse from one cell to another in the central nervous system, which prevents over-firing of the nerve cells. It is also used for brain metabolism and to treat both epilepsy and hypertension where it is thought to induce tranquility in individuals who have a high activity of manic behavior and acute agitation. In combination with inositol and nicotinamide it helps with blocking anxiety and stress related impulses from reaching the motor centers of the brain. Gamma-Aminobutyric Acid can be used to calm a person, much like tranquilizers, but without the possibility of addiction.