Cefaclor is a semi-synthetic cephalosporin antibiotic with a broad spectrum of bactericidal activity against certain Gram-positive and Gram-negative micro-organisms, chemically related to penicillin. It is effective against many different bacteria organisms, such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, E. coli, and many others. It is chemically designated as 3-chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid monohydrate. The chemical formula for cefaclor is C15H14ClN3O4SH2O and the molecular weight is 385.82. Cefaclor fights bacteria in the body. Cefaclor is used to treat many different types of bacterial infections such as bronchitis, tonsillitis, ear infections, skin infections, and urinary tract infections. Take all of the cefaclor that has been prescribed for you even if you begin to feel better.
Semisynthetic second generation cephalosporin antibiotic for oral administration. Usually active against the following organisms: Staphylococci species, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Proteus spp, Klebsiella spp, Haemophilus influenzae (including most beta lactamase producing ampicillin resistant strains), Neisseria gonorrhoeae, and several anaerobic bacteria (excluding Bacteroides fragilis). Note that pseudomonas spp and most strains of enterococci, enterobacter spp, indole positive proteus and serratia spp are resistant to cefaclor. Action results from inhibition of synthesis of cell wall mucopeptides.
Cefaclor is well absorbed after oral administration, whether taken with food or while fasting. However, when taken with food, the peak concentration is less and occurs later than that observed when the medicine is administered to fasting subjects. Widely distributed throughout body fluids and tissues. Does not penetrate the CSF. Approximately 60-85% of the drug is excreted unchanged in the urine. Elevated serum concentrations may be reduced by haemodialysis.