Chlorhexidine

Chlorhexidine is used to prevent and treat the redness, swelling, and bleeding gums associated with gingivitis. It is classified as an antimicrobial drug. Chlorhexidine (Hibiscrub; ICI) is generally accepted to be effective as an antiseptic hand wash for methicillin-susceptible Staphylococcus aureus (MSSA).

Chlorhexidine is obviously an easily tolerated and effective antiseptic for the daily practice and surgery. Its oral use is also well documented (e.g. in ill subjects who cannot brush their teeth adequately). However, the teeth discolorations that are caused by the drug are disturbing. It has not yet been established whether chlorhexidine plays a role in the eradication of streptococcus mutans in the prevention of caries.

Chlorhexidine is antiseptic agent effective against plaque, oral flora including Candida sp. Cleanser for surgical scrub, skin wounds, germicidal hand rinse, antibacterial dental rinse. Chlorhexidine is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast Antiseptic agent is a substance which kills or inhibits the growth of disease-causing bacteria and other microorganisms. It is essentially nontoxic to to be applied to the skin or mucous membranes. (Disinfectant including cresol, bleaching powder, and phenol is in general toxic to cells of the body). Common antiseptic agents are Benzalkonium Chloride, Cetrimide, Chlorhexidine, Hexachlorophene, Iodine Compounds, Mercury Compounds (Thimerosol), Alcohol and Hydrogen Peroxide, Hexamine Hippurate, Triclosan, Cetylpyridinium Chloride, And Dequalinium. Other substances which can be used for antiseptic purpose include Boric acid and volatile oils such as Methyl Salicylate.

Hexachlorophene and Benzalkonium Chloride are used primarily in hand or face washes. Benzalkonium Chloride must not be applied to areas which have not been fully rinsed as it is inactivated by organic compounds. Benzalkonium application many include disinfecting instruments and preservativing drugs in low concentration form.

Iodine compounds have the widest spectrum of antiinfectives against bacteria, fungi, spores, protozoa, viruses, and yeasts. Aqueous iodine are less effective than alcoholic solutions, but alcoholic component is drying and irritating to abraided skin. Povidone iodine is convenient to use as it is less irritating, but not as effective.

Chlorhexidine is used as a safe antiseptic or disinfectant to apply to prevent body infection and in oral rinses for treating sore gums and mouth ulcers and preventing plaque on teeth. It is used in the form of acetate, gluconate or hydrochloride, either alone or in combination with others such as cetrimide.

Cetrimide is an antiseptic agent with detergent properties. It has the wide spectrum of antiinfectives against bacteria and fungi. It is used as an ingredient of shampoos for treating seborrhoea and psoriasis. A very dilute solution can be applied topically for the relief of sore gums.

Hippuric Acid, an amino acid glycine, is excreted from the body and is used in urinary system drugs. Hexamine hippurates is helpful for preventing and treating infections of the urinary system; it acts by being transformed to formaldehyde.

Triclosan is a very popular antibacterial agent. It is used in hospitals for cleansing and disinfecting the skin of patients and surgeons. It is used in cosmetics, household goods and personal care products. It is also used in plastics and textiles for antibacterial activity purpose.

Cetylpyridinium chloride is used in oral rinses for cleaning mouth and treating minor throat or mouth infections and teething problems.
Dequalinium chloride is antiinfectives against bacteria and fungi. It is used in treating bacterial or fungal infections of mouth and throat.

CAS NO: 55-56-1
Common Name:1,1-Hexamethylenebis[5-(4-chlorophenyl)biguanide]
Molecular formula:C22H30CL2N10
Molecular weight:505.46
Specification:(Quality Standard:CP2000, JP13, BP99, USP23)
Appearance: White to pale yellow powder
Content: 98% min.
Melting point: 134-136 degree C
p-Chloroaniline content: 200PPM max.
Moisture content: 0.5% max.
Residue on ignition: 0.15% max.
Package: Packed in polybag to a paper drum of 10Kgs, 25Kgs.