Clindamycin phosphate is a water soluble ester of clindamycin and phosphoric acid. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin. The molecular formula is C18H34CIN2O8PS and the molecular weight is 504.96. Clindamycin Phosphate is a semisynthetic antibiotic produced by a chloro- substitution of a hydroxyl group on the parent compound, (and also an antibiotic) lincomycin. It occurs as a white to off-white, hygroscopic, crystalline powder. It is freely soluble in water, slightly soluble in dehydrated alcohol, very slightly soluble in acetone and practically insoluble in chloroform, benzene, and ether. Clindamycin phosphate is odorless or practically odorless, and has a bitter taste. Clindamycin is therefore a base (the lone pairs on the nitrogen groups act as bases) albeit a very weak one.
Clindamycin phosphate has activity against a wide variety of bacteria, including the bacteria associated with acne, Propionebacterium acnes. This is a common type of bacteria that feeds on sebum produced by the sebaceous glands in the skin. It produces waste products and fatty acids that irritate the sebaceous glands, making them inflamed and causing spots.
Clindamycin works by preventing the bacteria from producing proteins essential to the bacterial cell. Without these proteins the bacteria cannot grow, replicate and increase in numbers. By controlling bacterial numbers, the inflammation of the sebaceous glands is brought under control, and the skin is allowed to heal. Clindamycin phosphate prevents the bacterial cell from making protein so the cell dies. Clindamycin phosphate is used to treat gram positive and negative bacteria.
Clindamycin is indicated in the treatment of anaerobic infections, including Bacteroides species. Its antibacterial spectrum of activity comprises gram-positive microorganisms (excluding enterococci), Staphylococcus aureus and Staphylococcus epidermidis (including penicillinase-producing strains). Streptococci and pneumococci are also susceptible to clindamycin.