Dopamine Hydrochloride

Dopamine (Dopamine Hydrochloride) is the immediate precursor of epinephrine in the body. Exogenously administered, it produces direct stimulation of beta-1 receptors and variable (dose-dependent) stimulation of alpha receptors (peripheral vasoconstriction). Will cause a release of norepinephrine from its storage sites . These actions result in increased myocardial contraction, CO, and SV, as well as increased renal blood flow and sodium excretion. Exerts little effect on DBP and induces fewer arrhythmias than are seen with isoproterenol. Onset: 5 min. Duration: 10 min. t1/2: 2 min. Does not cross the blood-brain barrier. Metabolized in liver and excreted in urine.

Dopamine, a sympathomimetic amine vasopressor, is the naturally occurring immediate precursor of norepinephrine. Dopamine hydrochloride is a white to off-white crystalline powder, which may have a slight odor of hydrochloric acid. It is freely soluble in water and soluble in alcohol. Dopamine HCl is sensitive to alkalies, iron salts, and oxidizing agents. Chemically it is designated as 4-(2-aminoethyl) pyrocatechol hydrochloride, and its molecular formula is C8H11NO2•HCl. The molecular weight is 189.64.

Dopamine hydrochloride injection is a clear, practically colorless, sterile, pyrogen-free, aqueous solution of dopamine HCl for intravenous infusion after dilution. Each milliliter of the 40 mg/mL preparation contains 40 mg of dopamine hydrochloride (equivalent to 32.31 mg of dopamine base). Each milliliter of the 80 mg/mL preparation contains 80 mg of dopamine hydrochloride (equivalent to 64.62 mg of dopamine base). Each milliliter of both preparations contains the following: Sodium metabisulfite 9 mg added as an antioxidant; citric acid, anhydrous 10 mg; and sodium citrate, dihydrate 5 mg added as a buffer. May contain additional citric acid and/or sodium citrate for pH adjustment. pH is 3.3 (2.5 to 5.0).

Dopamine must be diluted in an appropriate sterile parenteral solution before intravenous administration.

Chemical Name: 4-(2-aminoethyl)-1, 2-pyrocatechol hydrochloride
Molecular formula: C8H11NO2·HCL
Molecular weight: 189.64
CAS No.: 62-31-7

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