17-alpha hydroxyprogesterone caproate
Hydroxyprogesterone hexaxnoate is a synthetic hormone similar to the natural female sex hormone progesterone. It is used in the prevention of spontaneous abortion in women with a history of recurrent miscarriage (habitual abortion). Spontaneous abortion occurs when the body's levels of progesterone drop below the required level to maintain pregnancy. Therefore hydroxyprogesterone is used to maintain these levels and prevent miscarriage.
17-alpha hydroxyprogesterone caproate is a white or creamy-white, crystalline powder. Odourless or having a slight odour. Insoluble in water; soluble in ether; slightly soluble in benzene. Protect from light. Hydroxyprogesterone caproate is a progestogen structurally related to progesterone that has been used for recurrent miscarriage and various menstrual disorders. In recurrent miscarriage associated with proven progesterone deficiency, suggested doses have been 250 to 500 mg weekly by intramuscular injection during the first half of pregnancy.
17-alpha hydroxyprogesterone caproate is a wakly active, naturally occurring progesterone that has been isolated from both adrenal glands and corpora lutea. The synthetic caproate ester is virtually inactive when given by mouth but works as a long-acting progestin when administered intramuscularly.