Pregnenolone is a natural and body produced metabolite made from cholesterol. It is synthesized inside the mitochondria, the tiny "power plants" (up to 1000's per cell) found in each cell.
Pregnenolone is the basic precursor, or starting raw material, for the production of ALL the human steroid hormones, including DHEA, progesterone, estrogen, testosterone, cortisol and aldosterone, but pregnenolone is not itself steroid hormone. Pregnenolone serves as a precursor to other hormones, including dehydroepiandrosterone (DHEA) and progesterone.
Pregnenolone is the true "mother hormone," made directly from cholesterol within the mitochondria. In addition to memory enhancement, a partial list of pregnenolone's diverse benefits include: There is no negative feedback loop. Once produced, pregnenolone leaves the mitochondria so it cannot inhibit its own synthesis. Complete hormone balance. It does everything DHEA does and more. Unlike DHEA, pregnenolone readily converts into progesterone, a hormone essential to balance estrogen and reduce cancer risk, reduce "bad" cholesterol, build healthy bones and reduce the symptoms of menopause. Enzyme repair. The cytochrome P-450 enzyme system is stimulated by the addition of pregnenolone. This enzyme system is important in neutralizing cellular toxins. Protection from cortisol/cortisone. Cortisol levels increase with normal aging causing immune impairment, atherosclerosis, and neuronal injury. Pregnenolone protects against adrenal atrophy when withdrawing cortisone therapy. Pregnenolone helps protect against the effects of elevated cortisol including atrophy of the skin, osteoporosis, hot flashes in women and possibly adult-onset diabetes.
Pregnenolone shows many of the benefits of cortisol, it reduces allergic reactions, lessens arthritis inflammation and produces a relaxing and mildly euphoric "stress buffer effect", without any of the negative side effects of cortisol. Pregnenolone improves mood, and has a mild anti-depressant effect at doses of 50mg to 200mg per day, and also improves energy levels by protecting our energy producing mitochondria from toxins, which would otherwise damage the mitochondria. Pregnenolone also enhances the activity of the cytochrome P450 detoxifying enzymes, which help our cells (especially the liver and brain) to detoxify poisons of all sorts, whether from the outside world, or our own metabolically produced toxins. Pregnenolone is generally safe and effective at doses of 25mg to 200mg per day.