Sulpiride is a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. It is an anti-psychotic medication, chemically different from other antipsychotic drugs. Like all antipsychotic drugs, sulpiride is thought to work by blocking dopamine receptors in the brain. However, most of the antipsychotic drugs have a variety of actions, which can lead to a number of adverse effects and may account for some of the therapeutic benefits.

Sulpiride is a substituted benzamide neuroleptic which is used as an antipsychotic and also as an antidepressant/ anxiolytic in some countries. It exerts antipsychotic action, antiemetic actions and has an effect on gastrin secretion. Antipsychotic effects occur at daily oral doses of 400-1800 mg daily with a maximum reported daily dose of 3600 mg. Antidepressant effects generally occur at lower daily doses (50-300 mg). The plasma half-life of sulpiride is 6-8 h. Sulpiride is excreted largely as unchanged drug in urine. Sulpiride reduces both the positive and negative symptoms of schizophrenia. Sulpiride is a selective dopamine-D2 antagonist with antipsychotic and antidepressant properties. Blockade of dopamine D2 receptors in the mesolimbic area of the brain reduces hallucinations and delusions.

Sulpiride is effective in the treatment of acute and chronic schizophrenia but does not appear to offer a significant advantage over other antipsychotic agents; it has also been investigated in Huntington's disease, duodenal ulcer, poor lactation, contraception, depression, and for the treatment of tardive dyskinesia.