Clofibrate is a lipid lowering agent used along with your diet to control high cholesterol and triglyceride levels in the blood. Clofibrate decreases the liver's production of triglycerides and bad cholesterol (low density lipoprotein). It is not known how the good cholesterol (high density lipoprotein) is increased.
Clofibrate is used to lower high levels of cholesterol (a type of fat) in the blood. Clofibrate is especially good at lowering triglycerides and very-low-density lipoprotein (VLDL) (a form of cholesterol). Clofibrate may also be used for purposes other than those listed in this medication guide.
Action/Kinetics: Decreases triglycerides and VLDL; cholesterol and LDL are decreased less predictably and less effectively. Mechanism may be due to increased catabolism of VLDL to LDL and decreased synthesis of VLDL by the liver. Cholesterol formation is inhibited early in the biosynthetic chain; excretion of neutral streoids is increased. Peak plasma levels: 3-6 hr. t1/2 plasma: 15 hr. Therapeutic effect: Onset, 2-5 days; maximum effect: 3 weeks. Triglycerides return to pretreatment levels 2-3 weeks after therapy is terminated. Hydrolyzed to the active p-chlorophenoxyisobutyric acid which is further metabolized and excreted in the urine. Drug may concentrate in fetal blood. LFTs should be performed during therapy.
Uses: Dysbetalipoproteinemia (type III hyperlipidemia) not responding to diet. Hyperlipidemia (types IV and V) with a risk of abdominal pain and pancreatitis not responding to diet.
CAS Number: 637-07-0
Chemical Formula: C12H15ClO3