Cyproterone acetate is an anti-androgen; it competes at the receptor sites (Q2.8) with androgens and reduces their effects. Dianette (Schering) is a special combined oral contraceptive pill that contains 2mg cyproterone acetate.
Cyproterone acetate is used to reduce sex drive in men which have excessive sex drive and for the treatment of pronounced sexual aggression. It is also prescribed to treat severe hirsuitism in woman of childbearing age and also androgenetic alopecia in women. Like cimitedine and other similar type drugs Cyproterone acetate exerts its effects by blocking the binding of DHT dihydrotestosterone to its receptors.
Cyproterone acetate is used in the treatment of prostate cancer. It works by preventing testosterone from binding to androgen receptors in the prostate gland. It also acts on an area of the brain called the hypothalamus, which ultimately results in a reduction in the amount of testosterone produced by the body. It therefore starves prostate cancer cells of testosterone, which prevents them growing. Eventually the prostate tumour will shrink. It is a type of hormonal therapy. Hormonal therapies interfere with the production or action of particular hormones in the body. Hormones are substances produced naturally in the body. They act as chemical messengers and help to control the activity of cells and organs. Most prostate cancers need supplies of the male hormone testosterone to grow. This is produced by the testes and adrenal glands. On the surface of the prostate cancer cells are proteins called receptors. Cyproterone acetate has a structure similar to testosterone. It works by attaching itself to the receptors on the surface of the prostate cancer cells to block and prevent the attachment of testosterone. Without testosterone, the cancer cells either grow more slowly or stop growing altogether.
Cyproterone Acetate is a steroidal antiandrogen. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. The addition of low dose diethylstilbestrol has been found to almost entirely suppress testosterone activity. Cyproterone acetate is also known to block dihydrotestosterone from binding to receptors in prostatic carcinoma cells. In addition, cyproterone acetate has a weak progestational activity that results in the partial suppression of pituitary gonadotropin. This subsequently has the effect of decreasing serum testosterone levels.
Cyproterone acetate my act as a direct antiandrogen drug it has the effect of lowering androgen hormone production. With lower levels of testosterone and by blocking the binding of dihyrotestosterone (DHT) to DHT receptors, cyproterone may be effective at limiting hair loss due to the effects of androgens.
Cyproterone acetate is used for women who have too much androgen production and/or seem to be overly sensitive to androgen activity in their bodies. Cyproterone acetate is used for acne and/or overactive oil glands and hirsutism as well as androgen dependent hair loss. In men, cyproterone acetate is used for prostate cancer treatment, to reduce sex drive in men, for the treatment of sexual aggression, and for use by male to female transsexuals in conjucntion with estrogen supplements. Genrally cyproterone acetate is not given to men for androgen hair loss due to the nature of side effects in men as compared to women.
Cyproterone acetate is an anti-androgen and blocks the normal activity of the slight amount of male type hormone called androgen which every woman normally produces and is necessary for axillary and pubic hair formation and maintenance. Cyproterone can be highly effective in many women with excess sexual sited hair (called hirsutism). However, it can take a year of treatment before the excess hairs are lost but as the hairs invariably return rapidly on cessation of the drug, it will be necessary to continue taking cyproterone as long as you wish to remain without excess hairs.
Androgens are male hormones such as testosterone. They have many actions in the body and work by binding to receptors on cells and influencing the actions of these cells. Prostate cancers generally require the androgen testosterone in order to grow and spread.
Chemical Name: 6-Chloro-1α,2α-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate
Molecular Formula: C24H29ClO4
CAS NO: 427-51-0