Enrofloxacin is a broad-spectrum antibiotic used to treat infections in animals caused by susceptible bacteria. Enrofloxacin belongs to a general class of antibiotics known as fluoroquinolones. Other related drugs in this class include ciprofloxacin. Enrofloxacin is thought to inhibit the synthesis of DNA within the bacteria, resulting in bacterial death. Enrofloxacin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
Enrofloxacin is used to treat a variety of infections, including skin infections, urinary tract infections, respiratory infections and wound infections caused by susceptible bacteria. Enrofloxacin is not effective for treating infections caused by viruses, parasites or molds.
Its activity is concentration dependent. The mechanism of action is to inhibit bacterial DNA-gyrase, prevent DNA supercoiling and synthesis. It has activity against some gram positive aerobes and a wide range of gram negative bacilli and cocci, which include Klebsiella, Pseudomonas, Salmonella, and other organisms such as Mycoplasma, Staphylococci and Chlamydia .
The mode of action of enrofloxacin is bactericidal by inhibition of DNA-gyrase, an essential bacterial enzyme. In vitro and in vivo activity has been demonstrated against Escherichia coli in chickens and against Escherichia coli and Pasteurella multocida in turkeys, major pathogens associated with mortality.
Molecular formula: C19H22FN3O3
Molecular weight: 359.40
CAS Number: 93106-60-6