Fenofibrate is a fibric acid derivative. Fenofibrate helps reduce types of fat in the blood. Fenofibrate is especially good at lowering triglycerides and a form of cholesterol called very-low-density lipoprotein (VLDL). High levels of these types of fat in the blood are associated with an increased chance of pancreatitis, an inflammation of the pancreas that can result in severe stomach pain and even death.
Fenofibrate lowers elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fenofibrate increases the high density lipoprotein (HDL) cholesterol fraction.
Fenofibrate appears to have a greater depressant effect on the very low density lipoproteins (VLDL) than on the low density lipoproteins (LDL). Therapeutic doses of fenofibrate produce variable elevations of HDL cholesterol, a reduction in the content of the total low density lipoproteins cholesterol, and a substantial reduction in the triglyceride content of very low density lipoproteins.
Fenofibrate enhances the liver elimination of cholesterol as bile salts, inhibits the biosynthesis of triglycerides and enhances the catabolism of VLDL by increasing the activity of lipoprotein lipase, has an inhibitory effect on the biosynthesis of cholesterol by modulating the activity of HMG CoA reductase.
Molecular formula: C20H21ClO4
Molecular weight: 360.50
Chemical Name : 2-[4-(4Chlorobenzoyl phenoxy)]-2-methyl propionic acid-1-methyl ethyl ether
CAS No.: 49562-28-9