China Greatvista Chemicals

Ketoprofen

Ketoprofen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ketoprofen works by reducing hormones that cause inflammation and pain in the body. Ketoprofen is used to reduce pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and abdominal cramps associated with menstruation.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis, and other musculoskeletal conditions. Since the response to different NSAIDs varies from patient to patient, it is not unusual for a doctor to try different NSAIDs for any given condition.

Ketoprofen is used for the treatment of inflammation and pain caused by rheumatoid arthritis and osteoarthritis, as well as soft tissue injuries, such as tendinitis and bursitis. Orudis is immediately released into the blood and is also used for rapid relief of mild to moderate pain and menstrual cramps. Oruvail is slowly released into the blood and is generally not useful in situations where prompt pain relief is desired.

The chemical name for ketoprofen is 2-(3- benzoylphenyl)- propionic acid. Its empirical formula is C12H12O2, with a molecular weight of 254.29. It has a pKa of 5.94 in methanol: water (3:1) and an n-octanol: water partition coefficient of 0.97 (buffer pH 7.4). Ketoprofen is a white or off-white, odorless, nonhygroscopic, fine to granular powder, melting at about 95º C. It is freely soluble in ethanol, chloroform, acetone, ether and soluble in benzene and strong alkali, but practically insoluble in water at 20º C. Ketoprofen is a pain reliever with anti-inflammatory effects. It is not aspirin, but some persons with sensitivity or allergy to aspirin may have the same reaction to ibuprofen. Ketoprofen is especially helpful for the pain of bruises and sprains. Its anti-inflammatory effects make it useful for tendonitis.