Ofloxacin is an antibiotic in a class of drugs called fluoroquinolones. Ofloxacin fights bacteria in the body. Ofloxacin is used to treat various bacterial infections such as bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate. Ofloxacin is an alternative to ciprofloxacin used when there are contraindications to the use of ciprofloxacin itself. Ofloxacin inhibits an enzyme called DNA gyrase that is an essential component of the mechanism that passes genetic information onto daughter cells when a cell divides.
Ofloxacin belongs to a group of broad spectrum antibiotics called the quinolones. It works by entering the bacterial cell and inhibiting a chemical called DNA-gyrase which is involved in the production of genetic material (DNA). This therefore prevents the bacteria from reproducing and their growth is stopped. Ofloxacin is effective against several types of bacteria that tend to be resistant to other commonly used antibiotics. It is used to treat a wide range of infections, including infections of the chest, urinary tract. It is also used as a single dose treatment for gonorrhoea.
Action/Kinetics: Effective against a wide range of gram-positive and gram-negative aerobic and anaerobic bacteria. Penicillinase has no effect on the activity of ofloxacin. Widely distributed to body fluids. Maximum serum levels: 1-2 hr. t1/2, first phase: 5-7 hr; second phase: 20-25 hr. Peak serum levels at steady state, after PO doses: 1.5 mcg/mL after 200-mg doses, 2.4 mcg/mL after 300-mg doses, and 2.9 mcg/mL after 400-mg doses. Between 70% and 80% is excreted unchanged in the urine. Many common infections in humans are caused by single cell living organisms called bacteria. Bacteria invade the body, and then grow, multiply, and spread. Medicines that control and eradicate these bacteria are called antibiotics. Ofloxacin is an antibiotic that stops bacteria multiplication by inhibiting the reproduction and repair of their genetic material (DNA).