Pyridostigmine bromide is a pretreatment drug used to protect against the CW nerve agent soman. By itself PB is not protective against CW nerve agent poisoning. Pyridostigmine bromide (PB), a drug used to treat myasthenia gravis (MG).
Action/Kinetics: Has a slower onset, longer duration of action, and fewer side effects than neostigmine. Onset, PO: 30-45 min for syrup and tablets and 30-60 min for extended-release tablets; IM: 15 min; IV: 2-5 min. Duration, PO: 3-6 hr for syrup and tablets and 6-12 hr for extended-release tablets; IM, IV: 2-4 hr. Poorly absorbed from the GI tract; excreted in urine up to 72 hr after administration.
Pyridostigmine bromide inhibits the destruction of acetylcholine by cholinesterase and thereby permits freer transmission of nerve impulses across the neuromuscular junction. Pyridostigmine is an analog of neostigmine (Prostigmin), but differs from it in certain clinically significant respects; for example, pyridostigmine is characterized by a longer duration of action and fewer gastrointestinal side effects.
Molecular Formula: C9H13BrN2O2
Molecualr Weight: 261.12