Lisinopril is an antihypertensive agent useful in controlling high blood pressure by relaxing blood vessels. The drug works by inhibition of angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The beneficial effects of lisinopril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Side effects include fever and chills, hoarseness, swelling, stomach pain, itching, and yellow eyes or skin.
Lisinopril is used in the treatment of high blood pressure. It is effective when used alone or when combined with other high blood pressure medications. Lisinopril may also be used with other medications in the treatment of heart failure, and may be given within 24 hours of a heart attack to improve chances of survival. Lisinopril is a type of drug called an ACE inhibitor. Lisinopril (generic Zestril) works by reducing production of a substance that increases salt and water retention in your body.
Lisinopril works by causing blood vessels to relax, lowering blood pressure and increasing the supply of blood and oxygen to the heart. For this reason it is also sometimes used, alongside other medicines, to treat heart failure and circulatory problems associated with diabetes. It inhibits the action of angiotensin converting enzyme (ACE). This inhibition reduces blood pressure by preventing the formation of Angiotensin II, a biochemical produced by the kidney which increases blood sodium (greater water retention). It is usually used along with other drugs for high blood pressure.