China Greatvista Chemicals

D-Mannose

Mannose is a sugar, one of the hexose series of carbohydrates. Mannose enters the carbohydrate metabolism stream by phosphorylation and conversion to fructose-6-phosphate. Mannose is a monosaccharides. Containing six carbons and an aldehyde group, it is classified as an aldose and a hexose. Mannose is a constituent of glycoproteins and a few polysaccharides. Mannose is phosphorylated by hexokinase to mannose-6-phosphate, which is readily isomerized to fructose-6-phosphate for entry into glycolysis or gluconeogenesis. Mannose can be formed by the oxidation of mannitol. The root of both these words is mannna, the food supplied to the Isrealites during their journey through Arabia (divinely supplied), which is the sweet secretion of several trees and shrubs, such as fraxinus ornus.

D-Mannose, which appears in some fruits including cranberry, may prevent adhesion of bacteria to tissues of the urinary tract and bladder. D-Mannose is a natural occurring simple sugar that appears to be a safe, practical alternative for the treatment of urinary tract infections (UTI's). D-Mannose is absorbed eight times slower than glucose, and when ingested, is not converted to glycogen or stored in the liver, but rather goes directly to the blood stream from the upper GI tract. Hence, D-Mannose is mostly filtered through the kidneys and routed to the bladder.

The bladder lining is comprised of polysaccharide molecules. Finger-like projections on the cell surface of E. coli bacteria adhere to these molecules, initiating an infection. In the presence of D-Mannose, E. coli preferentially attach to D-Mannose molecules forming a complex which is expelled with the next voiding.

D-Mannose probably works 80-90% of the time because the bacteria disabled by Mannose causes 80-90% of UTI’s. Whereas antibiotic treatment radically changes GI bacterial populations required for good health, potentially causing fungal or gastrointestinal infections, D-Mannose removes “bad” bacteria by attachment and voiding.

Mannose occurs in two different isomers known as mannopyranose and mannofuranose, which contain 6 carbon, 12 hydrogen, and 6 oxygen atoms per molecule and feature a melting point of 132 degrees Celsius. In nature, the saccharide is found in glycolipids and glycoproteins of certain plants, fungi, and bacteria in polymerized forms known as mannans, which act as food energy supplies. The enzyme hexokinase may phosphorylate mannans to form mannose-6-phosphate, a substance that isomerizes to fructose-6-phosphate before entering into the glycolysis or gluconeogenesis metabolic pathways.

Synonyms: seminose, carubinose
Molecular formula: C6H12O6
CAS No: 3458-28-4