Pyrimidine is an organic compound, similar to benzene, but with a heterocyclic ring: two nitrogen atoms taking the place of carbon atoms at positions 1 and 3 relative to each other around the six-member ring.
Three bases of the nucleic acids, namely cytosine, thymine, and uracil, are pyrimidine derivatives. In DNA, these bases form hydrogen bonds with their complementary purines.
Pyrimidine is a heterocyclic compound containing nitrogen atoms at positions 1 and 3 in six-membered ring structure molecule. The simplest one is Pyrimidine itself and the three major purines in living systems are cytosine, thymine, and uracil. Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. They can be the parent compound of many drugs, including the barbiturates.
Pyrimidine nucleotides play a key role in RNA and DNA synthesis, in the activation of sugars as a prerequisite for glycosylation of proteins and lipids, polysaccharide synthesis and detoxification. Recently uridine - like adenosine - has been regarded as modulator of blood flow and functions in the peripheric and central nerve system. The separate role of the intermediate orotic acid is a matter of controverse. Perturbation in pyrimidine metabolism results in growth retardation and neurological disorders. Pyrimidine and purine nucleoside analogues and anti-pyrimidine agents are among the most widely used drugs in chemotherapy, immunosuppression, viral infection and parasitic disease.
Synonyms: 1,3-diazabenzene, m-diazine, 1,3-diazine, metadiazine, miazine
Molecular formula: C4H4N2
CAS No: 289-95-2