Uridine is a part of the pyrimidine family. Uracil attaches to the sugar ribose to form a glycosidic linkage, and the resulting compound is uridine. Its involvement in the biosynthesis of RNA demonstrates that uridine is important in the translation of genetic information. Uridine is present in every cell of the human body.
Uridine is a pyrimidine or a two ring structure that hydrogen bonds to a purine to complete a stable structure. A carbon sugar ring attaches to nitrogen in the base to form an N-glycosylic bond. The nitrogenous bases, which are primarily nonpolar, pack tightly enough to exclude water and from a stable, primarily nonpolar environment in the helix interior.
Uridine is a particular "nucleoside" which is used by our body to produce DNA. Uridine is also required for many other metabolic pathways - for example uridine is needed to produce glycogen. Uridine is a natural substance in our body. Humans are normally able to produce uridine, but the ability to do so requires intact mitochondria.
Uridine is one of four nucleosides used in genetic coding for RNA, and its complement is the nucleoside adenosine. Each molecule of uridine is comprised of 9 carbons, 12 hydrogens, 2 nitrogens, and 6 oxygen atoms, resulting in a molecular weight of 244.20. The melting point of purified crystalline needles of uridine, which are soluble in water, is 165 degrees Celsius. Within the body, the nucleoside plays an important role in the metabolism of carbohydrates, and, in the laboratory, the white odorless powder that can be extracted from yeast ribonucleic acids using a weak alkali solution is utilized in a variety of biochemical experiments and studies.
Due to their therapeutic capacity, a number of nucleotide analogues are often chemically synthesized for medicinal use. When certain uridine derivatives are, for instance, utilized with organ transplant procedures, the likelihood of organ rejection by the recipient is reduced due to immune system repression. Also, mitochondrial disease, which is typically associated with neurological problems and a decrease in cognitive ability as well as kidney and muscular malfunction, may be potentially improved when triacetyluridine (TAU) is administered to sufferers. TAU is a precursor of uridine that rapidly converts to the nucleoside when consumed orally.
Uridine is a nucleoside containing uracil. Uridine differs from uracil in containing a sugar (ribose). Phosphorylation of uridine produces a nucleotide found in RNA. Deoxyuridine is a related nucleoside that contains deoxyribose instead of ribose as the sugar. Uridine is a biological compound essential for the synthesis of DNA and RNA, and numerous other factors essential for cell metabolism. Uridine is synthesized by the power plant of the human cell known as the mitochondria.
Chemical formula: C12H18N2O10
CAS No: 58-96-8
Other names: Uridine-5-oxyacetic acid