Biotin, D-Biotin (Vitamin H, Vitamin B7)
Biotin, also known as vitamin H or B7 and C10H16N2O3S (Biotin; Coenzyme R, Biopeiderm), is a B-complex vitamin which is important in the catalysis of essential metabolic reactions to synthesize fatty acids, in gluconeogenesis, and to metabolize leucine.
Biotin is a water-soluble vitamin produced in the body by certain types of intestinal bacteria and obtained from food. Considered part of the B complex group of vitamins, biotin is necessary for the metabolism of carbohydrates, fats, and amino acids (the building blocks of protein).
Deficiency, uncommon in humans, may result in hair loss, dry scaly skin, cracking in the corners of the mouth (called cheilitis), swollen and painful tongue that is magenta in color (glossitis), dry eyes, loss of appetite, fatigue, insomnia, and depression. Animals deficient in biotin during pregnancy are more likely to deliver newborns with birth defects such as a cleft palate. Research in this area for pregnant women is underway. One situation in which biotin deficiency does often develop is in people who have been on parenteral nutrition (nutrition administered intravenously rather than through the mouth or stomach) for a long period of time. It may also been seen in people who have been on long-term therapy with anticonvulsants, antibiotics, and sulfa drugs.
Biotin is a water-soluble member of the B-complex group of vitamins and is commonly referred to as vitamin H. The biochemical acts as a carrier for carbon dioxide in the pyruvate carboxylase reaction, where biotin is linked to the epsilon-amino group of a lysine residue in the enzyme. Biotin is necessary for both metabolism and growth in humans, particularly with reference to production of fatty acids, antibodies, digestive enzymes, and in niacin (vitamin B-3) metabolism. Food sources for biotin are liver, kidney, soy flour, egg yolk, cereal, and yeast. There are suggestions that biotin is also capable of curing baldness, alleviating muscle pain and depression, and functions as a cure for dermatitis, although there is no substantial evidence for any of these claims. Biotin deficiency results in fatigue, depression, nausea, muscle pains, hair loss, and anemia.
Biotin comes in two forms, and it is alternately known as vitamin H and Coenzyme R. Biotin is integral to many of the activities of enzymes in the human body. It is necessary for the breakdown of fatty acids in the human body. Biotin is also essential for the breakdown of carbohydrates. It is integral to the conversion process which takes fatty acids and carbohydrates in the body and converts them into energy. This then allows for production of fats and excretion of protein breakdown products.
Product Name: D-Biotin
Chemical Name: Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid
CAS Registry Number: 58-85-5
Empirical formula: C9H19NO4
Molecular weight: 205.25