Troxerutin (Vitamin P4)
Troxerutin is a derivative of the natural bioflavonoid rutin extracted from Sophora japonica. Troxerutin is a mixture of hydroxyethylated rutins which contains not less than 80.0 % of 7,3´,4´-Tris[O-(2-hydroxyethyl)] rutin.
Trihydroxyethylrutoside, the principal flavonoid in troxerutin, is also known as 7, 3', 4'-tris [O- (2-hydroxyethyl)]rutin, trioxyethylrutin and 2- [3, 4-bis (2-hydroxyethoxy) phenyl]- 3 [[6 - O - (6 - deoxy-alpha-L-mannopyranosyl )-beta-D-glucopyranosyl]oxy] -5-hydroxy-7- (2-hydroxyethoxy) -4H-1-benzopyran-4-one. It is a solid, yellow substance that is soluble in water. Its molecular formula is C33H42O19, and its molecular weight is 742.69 daltons.
Hydroxyethylrutosides (HR) refer to a mixture of semi-synthetic derivatives of the flavonoid rutin. Rutin is a naturally occurring flavonol glycoside comprised of the flavonol quercetin and the disaccharide rutinose (see Rutin). Hydroxyethylrutosides are comprised of the mono-, di-, tri- and tetrahydroxyethyl derivatives of rutin and are prepared by the hydroxyethylation of the phenolic groups of rutin.
Formulations, mainly consisting of the trihydroxyethyl derivative of rutin, are used in Europe, Mexico and other Latin American countries for the treatment of such venous disorders as varicose veins and hemorrhoids. The generic name for these formulations is troxerutin.
Troxerutin is a standardised mixture of semi-synthetic flavonoids. These benzopyrone derivatives are obtained by introducing hydroxyethyl groups in the natural bioflavonoid rutin commonly extracted from Sophora japonica (Japanese pagoda tree). Troxerutin is mainly constituted by monohydroxyethylrutosides (~ 5%), dihydroxyethylrutosides (~ 34%), trihydroxyethylrutosides (~46%) and tetrahydroxyethylrutosides (~ 5%). Other hydroxyethylated components such as tetrahydroxyethyl-quercitin are also present in small quantities. Troxerutin is best suited for the treatment of the pre-varicose and varicose syndrome, varicose ulcers, trombophlebitis, post-phlebitic conditions, chronic venous deficiency, and hemorrhoids. Troxerutin can also be successfully applied for muscle pain and edemas due to traumaic vein blood-flow disorders and hematomes.
Molecular Formula: C33H42O19
Molecular Weight: 742.68
C.A.S. No.: 7085-55-4