Vitamin E Succinate
Vitamin E Succinate takes vitamin E's antioxidant action a step further. Succinate feeds directly into the Krebs cycle, our major metabolic pathway for generating energy. This extra dimension from succinate significantly extends the protective properties of vitamin E. Then why not have E as succinate in all antioxidant formulations? Because it is not strictly hypoallergenic. E succinate is prepared from a soy-source Vitamin E. However the amounts of residual soy sensitivity, Vitamin E succinate offers an exciting new dimension of the Vitamin E effect.
Vitamin E succinate is a derivative of vitamin E and has been shown to inhibit tumor cell growth. In one study, vitamin E succinate inhibited growth and induced apoptic cell death in estrogen-receptor-negative human breast cancer cell lines. Vitamin E succinate may be of clinical use in the treatment of aggressive human breast cancers, particularly those that are resistant to anti-estrogen therapy.
Vitamin E succinate enhances the Immune response and induces cellular differentiation and/or growth Inhibition. Patent Inhibitor of neuroblastoma. cells, murine melanoma cells, avian lymphoid cells, human HL-60 promyelocytic leukemia cells, and several human breast carcinoma cell lines. VES has been shown to modulate adenylate cyclase and cAMP-dependent protein, inhibit protein kinase C activity, bind to cellular vitamin E binding protein, suppress c-myc and c-H-ras oncogene expression, and regulate TGFb protein production. Also shown to induce apoptosis In RL cells.
Vitamin E is an essential fat-soluble vitamin. The general term vitamin E refers to eight naturally occurring and synthetic tocopherols and tocotrienols and their acetate and succinate derivatives. Although the naturally occurring forms of vitamin E have lipid-soluble antioxidant properties that protect cell membranes against damage by free radicals, the acetate and succinate derivatives that are esterified at the C-6 position of the chromanol ring do not have antioxidant properties unless the esterification is hydrolyzed and free tocopherol is regenerated.